Small alveolar macrophages are infected preferentially by HIV and exhibit impaired phagocytic function
نویسندگان
چکیده
منابع مشابه
Effect of bronchoalveolar lavage fluid from Pneumocystis carinii-infected hosts on phagocytic activity of alveolar macrophages.
Alveolar macrophages from Pneumocystis carinii-infected rats are defective in phagocytosis. To investigate whether this defect is due to a certain factor present in P. carinii-infected lungs, alveolar macrophages from uninfected rats were incubated with bronchoalveolar lavage (BAL) fluid samples from P. carinii-infected rats. Alveolar macrophages treated with these BAL fluid samples became defe...
متن کاملLipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles.
Phagocytic vesicles were isolated from rabbit alveolar macrophages and guinea pig polymorphonuclear leukocytes that had ingested emulsified paraffin oil. Phospholipids and their fatty acids were determined in whole cells and in the phagocytic vesicle and pellet fractions separated from them. The cholesterol-to-phospholipid ratios in the vesicle fractions were distinctly higher than those of the...
متن کاملEndothelial function is impaired in HIV-infected patients with lipodystrophy.
BACKGROUND Data supporting a link between body-fat distribution changes and cardiovascular disease risk in HIV-infected patients are scarce and contradictory. We evaluated endothelial dysfunction, an early event in the development of atherosclerosis, and pro-atherosclerotic plasma biomarkers in HIV-infected patients with lipodystrophy. METHODS HIV-infected patients with and without lipodystro...
متن کاملHIV-1 infection does not impair human alveolar macrophage phagocytic function unless combined with cigarette smoking.
OBJECTIVE Macrophages are an important reservoir for the HIV and contribute to innate lung defense by their ability to phagocytose, digest, and process invading pathogens. We hypothesized that HIV-1 infection may lead to a defect in the phagocytic activity of alveolar macrophages. DESIGN In order to test this hypothesis, the phagocytic activity of alveolar macrophages from asymptomatic HIV-1 ...
متن کاملEffect of calcium on superoxide production by phagocytic vesicles from rabbit alveolar macrophages.
Phagocytic vesicles from rabbit lung macrophages produced superoxide in the presence of NADH or NADPH. At 37 degrees C, these vesicles generated 51+/-7.8 nmol O(2) (-)/min per mg protein in the presence of 0.5 mM NADPH. The apparent K(m) for NADPH and NADH (66 and 266 muM, respectively), the pH optimum for the reaction (6.9), and the cyanide insensitivity were similar to properties of plasma me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2014
ISSN: 1933-0219,1935-3456
DOI: 10.1038/mi.2013.127